Services

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PRECLINICAL

Safety platform

  • Genotoxicity/Mutagenicity (Ames, micronucleus)
  • Cytotoxicity
  • Toxicity in vivo (rodent)
    • Acute and chronic safety
    • Maximum tolerated dose
  • Toxicokinetics on rodents (ADME)
    • Acute and chronic administration
  • Histopathology
  • Metabolic safety
    • Predicting drug interactions in vitro (IC50)


Bioavailability and ADME platform

  • Penetration of the intestinal barrier in vitro (Caco-2)
  • Penetration of human skin in vitro
  • Pharmacokinetic Studies
    • PK parameters (half life, clearance, ASC, etc.)
  • Metabolomics
    • Identification of structures and assay of biomolecules
    • Identification, purification and assay of metabolites
    • Enzyme models
      • Microsomes (liver, intestines, etc.)
      • Recombinant proteins (CYP and UGT)
      • Human hepatocytes
    • Enzyme parameters (affinity, velocity, clearance, etc.)


Efficacy platform

  • Inflammation
    • Multiplex screening in vitro of anti-inflammatory property (cytokines, transcription factors, messenger RNA)
      • Skin
      • Lung
      • Intestine
    • Animal models of inflammation (rodent):
      • Skin (TPA, UV)
      • Respiratory (Asthma)
      • Enteric (Crohn's disease, ulcerative colitis)
      • Joint (rheumatoid arthritis)
      • Food Intolerance/Allergies
    • Measurement of cell mediators in response to stress (prostaglandins, cytokines, transcription factors, etc.)
  • Cancer
    • Measurement of cytotoxicity and apoptosis
    • In-vitro antitumor screening (lung, breast, colon, prostate, skin, etc.).
    • Animal models of lung, bowel and prostate tumors (xenograft)
    • Histopathology
  • Metabolic disorders (animal models)
    • Hunger and satiety
    • Genetic lipid disorder
    • Induced hypercholesterolemia
    • Type II Diabetes
  • Infectious Diseases (animal model)
    • Clostridium difficile
  • Other
    • Animal model of nephrotoxicity


Cosmetic/cosmeceutical

  • Analysis of creams, gels, cosmetotextiles, etc.
  • in-vitro model of human skin
    • Absorption
    • Permeability
    • Distribution
  • Characterization of tracers and bioactive agents


Other services

  • Corporate training
  • Transfer of methods
  • Design of study protocols and related support
  • Animal care committee
  • Animal facility services and accommodation (rodents)



CHARACTERIZATION

Food chemistry

  • Antioxidant platform
    • ABTS (TEAC)
    • ORAC (lipophilic and hydrophilic)
    • HORAC
    • SORAC
    • NORAC
  • Functional foods
    • Polyphenols
    • Flavonoids
    • Catechins
    • Anthocyanins and pro-anthocyanidins
    • Profiles of fatty acids
    • Etc.
  • Nutritional Characterization
    • Energy
    • Proteins
    • Amino Acids
    • Fats
    • Carbohydrates
    • Vitamins (A, C, D, E)
    • Minerals
    • Allergens and toxins
    • Etc.


Analytical chemistry

  • Nutraceuticals
    • Phytosterols
    • Lycopene
    • Phospholipids
    • Stevioside and rebaudioside
    • Etc.
  • Natural Health Products
    • Analyses of Monographs
    • Assay of active ingredients and markers
      • Echinacea
      • Ginkgo Biloba
      • Garlic
      • Balsam fir
      • Etc.
    • Analysis of essential oils and derivatives
  • Inorganic chemistry
    • Assay of minerals
    • Trace elements
    • Heavy metals
  • Customized analysis and method development


Microbiology

  • Probiotics and microflora
    • Genotyping
    • Phenotyping
  • Antimicrobial power
  • Bacterial, viral and fungal cultures (containment 2)


Molecular biology

  • Cloning and vector construction
  • Recombinant Proteins
    • Expression
    • Purification
  • Gene expression (real-time PCR)
  • Protein expression
    • Western Blot
    • Immunohistochemistry
    • Immunofluorescence
  • Animal genotyping (sheep, etc.)


Immunology

  • Cytofluometry
  • Assays by ELISA (immunoglobulins, cytokines, etc.).
  • Phagocytic activity
  • Proliferative Activity of Lymphocytes
  • Antibody Production
    • Monoclonal (mouse)
    • Polyclonal (rabbit)


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